Adrenomedullin and Adrenomedullin Binding Protein-1 Attenuate Vascular Endothelial Cell Apoptosis in Sepsis

Adrenomedullin binding protein-1 modulates vascular responsiveness to adrenomedullin in late sepsis.

Adrenomedullin (AM), a potent vasodilatory peptide, plays an important role in initiating the hyperdynamic response during the early stage of sepsis. Moreover, the reduced vascular responsiveness to AM appears to be responsible for the transition from the early, hyperdynamic to the late, hypodynamic phase of sepsis. Although the novel specific AM binding protein-1 (AMBP-1) enhances AM-mediated ...

Adrenomedullin Binding Protein-1 Modulates Vascular Responsiveness to Adrenomedullin During the Late Stage of Sepsis

Modulation of cytokine responses by adrenomedullin and adrenomedullin binding protein-1 in macrophages: a novel pathway in sepsis.

Polymicrobial sepsis is a life-threatening disorder. Patients die of septic shock and multiple organ failure caused by lipopolysaccharide (LPS) and other bacterial products. A hyperdynamic phase is followed by shock and circulatory collapse. Myocardial dysfunction frequently accompanies severe sepsis and septic shock secondary to circulating depressant factors, including tumour necrosis factor-...

Adrenomedullin binding protein-1 is downregulated during polymicrobial sepsis in the rat.

We have previously shown that administration of adrenomedullin (AM) and AM binding protein-1 (AMBP-1) in combination maintains cardiovascular stability and reduces mortality in a rat model of sepsis. However, it is unknown whether AMBP-1 is reduced under the septic condition and, if so, whether lipopolysaccharide (LPS) plays a role in down-regulating AMBP-1. To determine this, male adult Spragu...

Adrenomedullin reduces endothelial hyperpermeability.

Endothelial hyperpermeability induced by inflammatory mediators is a hallmark of sepsis and adult respiratory distress syndrome. Increased levels of the regulatory peptide adrenomedullin (ADM) have been found in patients with systemic inflammatory response. We analyzed the effect of ADM on the permeability of cultured human umbilical vein endothelial cell (HUVEC) and porcine pulmonary artery en...